Serveur d'exploration H2N2

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Type A influenza (H2N2) viruses isolated in Leningrad in 1980

Identifieur interne : 002420 ( Main/Exploration ); précédent : 002419; suivant : 002421

Type A influenza (H2N2) viruses isolated in Leningrad in 1980

Auteurs : D. B. Golubev [Russie] ; G. I. Karpukhin [Russie] ; S. S. Galitarov [Russie] ; G. M. Denisov [Russie]

Source :

RBID : ISTEX:F97F75D7DDDFA04FA107C0C67304D665133F2C93

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English descriptors

Abstract

In April-May 1980, two independent outbreaks of influenza-like illness occurred in Leningrad among children's-home children aged from 3 months to 2 years (of 68 children under observation, 50 became ill) and among boarding-school pupils aged 15–17 years (of 50 pupils under observation, 13 became ill). A total of five influenza A virus strains were derived from one clinically healthy and three affected children of the children's home. Similar viruses were obtained from one affected boarding-school pupil and from an infected woman aged 24 years (a sporadic case within a household). On the basis of laboratory findings, all these seven strains were identified as influenza A H2N2 subtype strains. Six of the affected children showed significant seroconversion only to H2 haemagglutinin from February to May 1980. Type A influenza H2N2 virus was isolated from three persons, including the sporadic case, who also showed significant seroconversion to H2 haemagglutinin. H2N2 influenza A virus was isolated on two occasions, at a 7-day interval, from the girl N. Ju. Laboratory findings obtained from the study of the viruses isolated using up-to-date immunological and molecular-biochemical techniques enable us to conclude the following. The A/Leningrad/80 isolates belong to H2N2 sero-subtype. The viruses isolated are similar but not identical to the A/Singapore/I/57 reference strain in details of polypeptide and gene composition.

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DOI: 10.1017/S0022172400062914


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<div type="abstract">In April-May 1980, two independent outbreaks of influenza-like illness occurred in Leningrad among children's-home children aged from 3 months to 2 years (of 68 children under observation, 50 became ill) and among boarding-school pupils aged 15–17 years (of 50 pupils under observation, 13 became ill). A total of five influenza A virus strains were derived from one clinically healthy and three affected children of the children's home. Similar viruses were obtained from one affected boarding-school pupil and from an infected woman aged 24 years (a sporadic case within a household). On the basis of laboratory findings, all these seven strains were identified as influenza A H2N2 subtype strains. Six of the affected children showed significant seroconversion only to H2 haemagglutinin from February to May 1980. Type A influenza H2N2 virus was isolated from three persons, including the sporadic case, who also showed significant seroconversion to H2 haemagglutinin. H2N2 influenza A virus was isolated on two occasions, at a 7-day interval, from the girl N. Ju. Laboratory findings obtained from the study of the viruses isolated using up-to-date immunological and molecular-biochemical techniques enable us to conclude the following. The A/Leningrad/80 isolates belong to H2N2 sero-subtype. The viruses isolated are similar but not identical to the A/Singapore/I/57 reference strain in details of polypeptide and gene composition.</div>
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